The Gazetteer

'The difference between a free spirit and a freeloader is three chords on the guitar.' T. Snider (via JJ Walker)

Friday, August 21, 2026

How Do You Make A 'Deal' With People Like This?

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FromTheDiaryOfA MadeManVille I really am trying to lay off the political stuff, honest I am. But jeepers... From the lede of a piece by Oliv...
8 comments:
Saturday, August 15, 2026

About That New Pancreatic Cancer Drug...

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  GTPaseActivatingActivity? WeDon'tNeedNoStinkingGTPaseActivatingActivityVille   As we discussed in earlier posts , I spent some time ma...
6 comments:
Saturday, July 04, 2026

Kraut Rock Prop Wash A-Go-Go

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IsItStillFunFunFunOnTheAutoHahn NotKraftwerkVille Just in case you were wondering... Those German-built, import duty-waived ferries that wer...
2 comments:
Wednesday, July 01, 2026

How To Drug An Oncogene.

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OfIbsAndAbs AndDownstreamEffectorsVille In the last post I mentioned that I worked with the powerful K-Ras oncogene to make experimental tu...
6 comments:
Monday, June 22, 2026

Of Oncogenes And Target Cells...

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Bipotency UberAllesVille I started gradual school 40 years ago. Luckily for me, a very smart woman agreed to let me come and work in her l...
13 comments:
Sunday, June 14, 2026

Back In Bow River, Again.

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WakeUpBluey You'llMissBrizzy I've been doing a lot of old mannish stuff recently. This includes helping my brother, who is doing al...
8 comments:
Sunday, April 26, 2026

My Evening Ride's Ultimate Destination

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Something'sHappeningRoundThere AshevilleVille Weirdly, it is not the real musician in the family who keeps me informed about what the k...
10 comments:
Saturday, March 21, 2026

Pedalling Towards Bedlam.

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WhatWouldJoanDidion WriteVille I don't know about you, but... I yearn for the brake of natural consequences to slow the spinning of a w...
39 comments:
Thursday, January 01, 2026

The Silliest Thing Ever Written?

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TheWeeklyStandard? NeverHeardOfItVille From America's number one conservative public intellectual... Or some such NYT/PBS/AtlanticMonthl...
14 comments:
Wednesday, December 31, 2025

Wither Gene Editing Blockbusters To Come?

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SometimesASequenceIsJust ASequence WhoseCorrectionMayBeTooSmallToProfitFromVille On Monday we talked a little bit about a new gene editing...
Tuesday, December 30, 2025

The Casinofication Of Everything, Reloaded.

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It'sNotJustTheWideWorldOfSports AnymoreVille From Judd Legum writing at his Substack: Two major news networks, CNN and CNBC, recently an...
2 comments:
Monday, December 29, 2025

A Truly Impressive Bit Of 'Prime' That Has Nothing Whatsoever To Do With Free Home Delivery.

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WillTheWondersNever CeaseVille Chronic granulomatous disease (CGD), one form of which is called p47GCD, is a condition wherein the affected...
3 comments:
Wednesday, December 24, 2025

Neither Velvet Nor Foggy.

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MayYourEarsBeMerry AndBrightVille If you need a little listening enjoyment for the next few days... Hear Mel Torme tell a super young Terry...
Saturday, December 20, 2025

The Rot At The Heart Of The Stream-O-Verse.

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WhatWouldBurlDo IvesVille From deep in the bowels of Reddit, one user shouts a high wattage truism out into the void... "(T)heir entir...
10 comments:
Thursday, December 18, 2025

The Advent Jukebox, Revisited!

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  It's Bigger E! Backed with the lost (old) boys of never lab... You can find more of E.'s advent jukebox offerings ....Here ....and...
4 comments:
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RossK
LeftCoast, Canada
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