There has been a lot of talk recently about the 'one dose of the Covid vaccine' approach to get it into as many people as quickly as possible.
The hot take media's ginning up of bad news after one dose has also begun and will no doubt only get worse.
But what do we actually know about single jab efficacy?
As Derek Lowe explains over at 'Science Translational Medicine Blogs', very little:
"...How protective is one dose?
We don’t know for (the AstraZeneca) vaccine, nor for the Pfizer/BioNTech one, nor for Moderna’s. No studies have been designed to find that out, so all we can do is guess based on what we’ve seen with the interval between doses in the two-dose studies. That’s been encouraging with the two mRNA vaccines, but remember: we don’t know how they are over a longer period, because no one was left without a second dose for that long. It’s certainly possible that without the second booster that the protection seen after one shot starts to wane. We do not know. And we know even less about the Oxford/AZ vaccine’s behavior under these conditions..."
So, what's driving this one dose approach and the rapid approval of the the adenoviral AstraZeneca vaccine in the UK?
...That situation in the UK appears to be one of the biggest factors driving the approval and rollout, and I see their point: this vaccine is indeed better than nothing, one shot for more people is likely to be better than two-shots-for-some, and it looks like they’re going to need all the help they can get. But “better than nothing” is a rough place to be....
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